Do affective or dissociative symptoms mediate the association between childhood sexual trauma and transition to psychosis in an ultra-high risk cohort?

A Thompson; S Marwaha; B Nelson; SJ Wood; PD McGorry; AR Yung; A Lin

Journal article

Do affective or dissociative symptoms mediate the association between childhood sexual trauma and transition to psychosis in an ultra-high risk cohort?

A Thompson, S Marwaha, B Nelson, SJ Wood, PD McGorry, AR Yung, A Lin

Psychiatry Research | Published : 2015

DOI: 10.1016/j.psychres.2016.01.017

Abstract

© 2016. We have previously reported an association between childhood sexual trauma and transition to psychosis in an Ultra High Risk (UHR) population. We aimed to investigate if this association was mediated by affective or dissociative symptoms. Data were from a large UHR for psychosis cohort study. None of the potential mediators (depression, anxiety, dissociation, mood swings and mania, assessed by the HAM-D, HAM-A and the CAARMS symptom scales) significantly mediated the total association between sexual abuse scores and transition. At the point of transition, the mechanistic pathway from sexual trauma to psychosis does not appear to operate through affective symptoms.

University of Melbourne Researchers

Andrew Thompson Author

Barnaby Nelson Author

Stephen Wood Author

Patrick McGorry Author

Related Projects (2)

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EMERGING MENTAL DISORDERS IN YOUNG PEOPLE: USING CLINICAL STAGING FOR PREDICTION, PREVENTION AND EARLY INTERVENTION

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Grants

Awarded by National Health and Medical Research Council (NHMRC)

Funding Acknowledgements

The study was funded by the Colonial Foundation Philanthropic Trust and a National Health and Medical Research Council (NHMRC) Program Grant (#566529).